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Commony used blood pressure medication may be effective in preventing epileptic seizures following traumatic brain injury

Epilepsy frequently results from a traumatic brain injury with reports that between 10 and 20 percent of all cases of epilepsy result from severe head trauma. There is now a report that a commonly used medication for high blood pressure can prevent many if not all seizures that take place following brain injury.

The information is reported in the current issue of the journal Annals of Neurology.

The drug, losartan (Cozaar®), prevented seizures in 60 percent of the rats tested, when normally 100 percent of the rats develop seizures after injury. In the 40 percent of rats that did develop seizures, they averaged about one quarter the number of seizures typical for untreated rats. Another experiment showed that administration of losartan for three weeks at the time of injury was enough to prevent most cases of epilepsy in normal lab rats in the following months.





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