«New study suggests that starting point of brain injury may be detectible in boxers | Home | New nonsurgical method being developed to monitor intracranial blood pressure»

Preventing cell death following brain injury

A new device called mechanical tissue resuscitation (MTR) to prevent cell death may dramatically change the way brain injuries are treated.  The device has been demonstrated in animal studies to reduce the size and extent of damaged tissue caused by traumatic brain injury according to a paper published in the journal Neurosurgery this month.

Tested in rodents, MTR uses negative pressure in order to create an environment that encourages cell survival.

The device has been utilized for the past fifteen years to treat wound and burn injuries.

In this study, the researchers used the device to remove toxins and fluids that cause cell death from an injury site located deep within the brain.

Brain injuries sustained by trauma or explosion causes irreversible cell damage and cell death at the site of the impact. Injured cells, in the area surrounding the wound, release toxic substances, which cause swelling of the brain, restricting blood flow and oxygen levels, which in turn causes further extensive cell death that affects brain function.

The research team set out in order to determine whether removing fluid and toxic substances from around injured brain cells could help improve survival of the damaged cells. The researchers found that in mice treated with MTR, brain swelling, as well as release of toxic substances considerably reduce compared to untreated brain injuries.

In addition, the device helped to preserve over 50% more brain tissue in animals treated with the MTR than in non-treated animals. After conducting behavioral function tests the team found that function returned faster in rodents treated with MTR.



TrackBack URL for this entry:
Trackback link

Listed below are links to weblogs that reference Preventing cell death following brain injury:


The comments to this entry are closed.